Two big names in research on aging, the Englishman Tom Kirkwood (University of Manchester) and American Michael Rose has developed this theory attractive as an explanation of senescence.
Tom KirkwoodLa disposable soma theory can be summarized as a Darwinian reading of aging, Tom Kirkwood at least claiming this affiliation.
According to two researchers, aging is caused by an accumulation of deg? Ts inflicted on somatic cells and tissues, because the repair functions of these cells and tissues are inadequate - and that evolution has so decided.
Repair systems have co? T energy. If this co? T reduces resources available for growth and reproduction, it will have a negative impact on Darwinian selection. So we can predict, according to this theory, that selection will favor a level sufficient enough maintenance to keep cells and organs in proper operating condition, but it will not promote cellular repair systems more sophisticated. In other words, this case has no interest in investing more than necessary for survival under conditions of normal existence. The optimal investment in systems repair and maintenance is one that maximizes the Darwinian selection, by definition, it is still smaller than it should be set? Implement to be immortal. So para Aging? T be a need for change.
The optimal investment level is the average life expectancy of the species, as determined by natural hazards in the environment. A case submitted by his environment to a high mortality (such as rodents) has more incentive to invest heavily in rapid growth and reproduction just as fast. In the case of humans, however, it is better to allocate a little more resources to maintenance functions and tissue repair. The acquisition of a greater longevity has co? T energy.
Several predictions derived from the disposable soma theory
Firstly, many different genes may contribute to aging. Secondly, differences in longevity between species can be explained by differences in mortality rates imposed by the environment. A species that lives in a dangerous ecological niche conna? Tra levels of mortality rates and the strength of natural selection will decline rapidly with the? Age resulting in a faster aging. Instead, any adjustment or change in ecological niche that reduces the level of risk opens the door to increased longevity because it can tip the balance toward greater investment in the repair and maintenance.
Kirkwood believes that the main factor to explain human longevity (the higher mammals) has been the increased brain volume, and reducing it went? Born in the level of environmental risk because of Increased intelligence and a growing social life. According to him, the disposable soma theory explains how, in the case of humans, a gradual reduction of environmental risk could lead to an increase in longevity, especially by strengthening the molecular mechanisms of repair and maintenance tissue. Kirkwood cites to support this correlation comparative studies showing that human cells have systems of DNA repair more efficient than cells of other mammals.
Tom KirkwoodLa disposable soma theory can be summarized as a Darwinian reading of aging, Tom Kirkwood at least claiming this affiliation.
According to two researchers, aging is caused by an accumulation of deg? Ts inflicted on somatic cells and tissues, because the repair functions of these cells and tissues are inadequate - and that evolution has so decided.
Repair systems have co? T energy. If this co? T reduces resources available for growth and reproduction, it will have a negative impact on Darwinian selection. So we can predict, according to this theory, that selection will favor a level sufficient enough maintenance to keep cells and organs in proper operating condition, but it will not promote cellular repair systems more sophisticated. In other words, this case has no interest in investing more than necessary for survival under conditions of normal existence. The optimal investment in systems repair and maintenance is one that maximizes the Darwinian selection, by definition, it is still smaller than it should be set? Implement to be immortal. So para Aging? T be a need for change.
The optimal investment level is the average life expectancy of the species, as determined by natural hazards in the environment. A case submitted by his environment to a high mortality (such as rodents) has more incentive to invest heavily in rapid growth and reproduction just as fast. In the case of humans, however, it is better to allocate a little more resources to maintenance functions and tissue repair. The acquisition of a greater longevity has co? T energy.
Several predictions derived from the disposable soma theory
Firstly, many different genes may contribute to aging. Secondly, differences in longevity between species can be explained by differences in mortality rates imposed by the environment. A species that lives in a dangerous ecological niche conna? Tra levels of mortality rates and the strength of natural selection will decline rapidly with the? Age resulting in a faster aging. Instead, any adjustment or change in ecological niche that reduces the level of risk opens the door to increased longevity because it can tip the balance toward greater investment in the repair and maintenance.
Kirkwood believes that the main factor to explain human longevity (the higher mammals) has been the increased brain volume, and reducing it went? Born in the level of environmental risk because of Increased intelligence and a growing social life. According to him, the disposable soma theory explains how, in the case of humans, a gradual reduction of environmental risk could lead to an increase in longevity, especially by strengthening the molecular mechanisms of repair and maintenance tissue. Kirkwood cites to support this correlation comparative studies showing that human cells have systems of DNA repair more efficient than cells of other mammals.
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